The Landsman Research Lab
for Pancreas Biology and Diabetes
Tel Aviv University
Our lab studies how the function of insulin-producing beta-cells is maintained in health, and why it is lost in diabetes.
To facilitate a therapy to diabetes, we study beta-cell development before and after birth.
To better understand these processes, we focus on the role of the pancreas microenvironment.
Research
Beta-cell development
Cell replacement therapy for diabetes requires a better understanding of the natural development of insulin-secreting beta-cells. To facilitate the generation of fully functional beta-cells, we focus on the role of the pancreatic microenvironment in beta-cell differentiation, proliferation, and functional maturation.
Beta-cell function and diabetes
Diabetes is associated with beta-cell dysfunction through a largely unknown mechanism.
To better understand this phenomenon, we identify microenvironmental cues that maintain insulin secretion in health and research how they change during disease progression.
