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 The Landsman Research Lab
for Pancreas Biology and Diabetes
Tel Aviv University 

Our lab studies how the function of insulin-producing beta-cells is maintained in health, and why it is lost in diabetes.

 

To facilitate a therapy to diabetes, we study beta-cell development before and after birth.

 

To better understand these processes, we focus on the role of the pancreas microenvironment.

Research

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Beta-cell development

Cell replacement therapy for diabetes requires a better understanding of the natural development of insulin-secreting beta-cells.

To facilitate the generation of fully functional beta-cells, we focus on the role of the pancreatic microenvironment in beta-cell differentiation, proliferation, and functional maturation.

Beta-cell function and diabetes

Diabetes is associated with beta-cell dysfunction through a largely unknown mechanism.

To better understand this phenomenon, we identify microenvironmental cues that maintain insulin secretion in health and research how they change during disease progression.

Latest Publications

The postnatal pancreatic microenvironment guides beta-cell maturation through BMP4 production

Sakhneny L, Mueller L, Schonblum A,Azaria S, Burganova G, Epshtein A, Isaacson A, Wilson H, Spagnoli FM, and Landsman L

 Developmental Cell (2021) Oct 11;56(19):2703-2711.e5

The Team

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